Zn 2+ -Triggered Amide Tautomerization Produces a Highly Zn 2+ -Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor
East China University of Science and Technology · Dalian University of Technology · +3 more institutions
Abstract
It is still a significant challenge to develop a Zn(2+)-selective fluorescent sensor with the ability to exclude the interference of some heavy and transition metal (HTM) ions such as Fe(2+), Co(2+), Ni(2+), Cu(2+), Cd(2+), and Hg(2+). Herein, we report a novel amide-containing receptor for Zn(2+), combined with a naphthalimide fluorophore, termed ZTRS. The fluorescence, absorption detection, NMR, and IR studies indicated that ZTRS bound Zn(2+) in an imidic acid tautomeric form of the amide/di-2-picolylamine receptor in aqueous solution, while most other HTM ions were bound to the sensor in an amide tautomeric form. Due to this differential binding mode, ZTRS showed excellent selectivity for Zn(2+) over most…
Citation impact
- FWCI
- 27.11
- Percentile
- 100%
- References
- 92
Authors
8- ZXZhaochao XuCorresponding
East China University of Science and Technology, Dalian University of Technology, Yonsei University, University of Cambridge, Ewha Womans University
- KBKyung-Hwa Baek
East China University of Science and Technology, University of Cambridge, Yonsei University, Dalian University of Technology, Ewha Womans University
- HKHana Kim
University of Cambridge, Dalian University of Technology, Yonsei University, East China University of Science and Technology, Ewha Womans University
- JCJingnan Cui
Yonsei University, University of Cambridge, Dalian University of Technology, East China University of Science and Technology, Ewha Womans University
- XQXuhong Qian
Yonsei University, Dalian University of Technology, University of Cambridge, Ewha Womans University, East China University of Science and Technology
Topics & keywords
- Chemistry
- Fluorescence
- Tautomer
- Amide
- Metal ions in aqueous solution
- Fluorophore
- Zinc
- Selectivity
- Reduced inequalities