articlePLoS ONEMar 14, 2012GOLD OA

Microvesicles Derived from Mesenchymal Stem Cells Enhance Survival in a Lethal Model of Acute Kidney Injury

SBStefania BrunoCGCristina GrangeFCFederica CollinoMCMaria Chiara DeregibusVCVincenzo Cantaluppi

University of Turin · Fresenius Medical Care (Germany)

PubMed
Indexed incrossrefdoajpubmed

Abstract

Several studies demonstrated that treatment with mesenchymal stem cells (MSCs) reduces cisplatin mortality in mice. Microvesicles (MVs) released from MSCs were previously shown to favor renal repair in non lethal toxic and ischemic acute renal injury (AKI). In the present study we investigated the effects of MSC-derived MVs in SCID mice survival in lethal cisplatin-induced AKI. Moreover, we evaluated in vitro the effect of MVs on cisplatin-induced apoptosis of human renal tubular epithelial cells and the molecular mechanisms involved. Two different regimens of MV injection were used. The single administration of MVs ameliorated renal function and morphology, and improved survival but did not prevent chronic…

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606
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Authors

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Topics & keywords

Topics
Keywords
  • Microvesicles
  • Mesenchymal stem cell
  • Acute kidney injury
  • Apoptosis
  • Cisplatin
  • In vivo
  • Cancer research
  • In vitro
UN Sustainable Development Goals
  • Good health and well-being
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