articleJournal of the American Chemical SocietyAug 17, 2004Closed access

A Synthetic DNA Walker for Molecular Transport

JSJong‐Shik ShinNANiles A. Pierce

California Institute of Technology

PubMed
Indexed incrossrefpubmed

Abstract

Inspired by kinesin movement along a microtubule, we demonstrate a processive bipedal DNA walker. Powered by externally controlled DNA fuel strands, the walker locomotes with a 5 nm stride by advancing the trailing foot to the lead at each step. Real-time monitoring of specific bidirectional walker movement is achieved via multiplexed fluorescence quenching.

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Authors

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Topics & keywords

Topics
Keywords
  • Chemistry
  • Molecular motor
  • Kinesin
  • DNA
  • Biophysics
  • Quenching (fluorescence)
  • Microtubule
  • Fluorescence
UN Sustainable Development Goals
  • Affordable and clean energy
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