articleJournal of Clinical InvestigationAug 17, 2007BRONZE OA

Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

MSMadhav SharmaBBBabak BabanPCPhillip ChandlerDHDe-Yan HouNSNagendra Singh

Discovery Institute · Augusta University · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO+ pDCs directly activate resting CD4+CD25+Foxp3+ Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor-draining LNs were constitutively activated and suppressed antigen-specific T cells immediately ex vivo. In vitro, IDO+ pDCs from tumor-draining LNs rapidly activated resting Tregs from non-tumor-bearing hosts without the need for mitogen or exogenous anti-CD3 crosslinking. Treg activation by IDO+ pDCs was MHC restricted, required an intact amino acid-responsive GCN2 pathway in the Tregs, and was prevented by CTLA4…

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Topics & keywords

Topics
Keywords
  • Indoleamine 2,3-dioxygenase
  • FOXP3
  • Downregulation and upregulation
  • Cancer research
  • Immunology
  • IL-2 receptor
  • In vivo
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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