MicroRNAs: Novel Regulators Involved in the Pathogenesis of Psoriasis?
Karolinska Institutet · Finnish Institute of Occupational Health · +1 more institution
Abstract
MicroRNAs are a recently discovered class of posttranscriptional regulators of gene expression with critical functions in health and disease. Psoriasis is the most prevalent chronic inflammatory skin disease in adults, with a substantial negative impact on the patients' quality of life. Here we show for the first time that psoriasis-affected skin has a specific microRNA expression profile when compared with healthy human skin or with another chronic inflammatory skin disease, atopic eczema. Among the psoriasis-specific microRNAs, we identified leukocyte-derived microRNAs and one keratinocyte-derived microRNA, miR-203. In a panel of 21 different human organs and tissues, miR-203 showed a highly skin-specific…
Citation impact
- FWCI
- 15.52
- Percentile
- 100%
- References
- 24
Authors
12Topics & keywords
- Psoriasis
- microRNA
- Pathogenesis
- Keratinocyte
- Immunology
- Biology
- Regulation of gene expression
- Inflammation
- Good health and well-being