Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders
University of Catania · University of Massachusetts Amherst · +1 more institution
Abstract
Despite the capacity of chaperones and other homeostatic components to restore folding equilibrium, cells appear poorly adapted for chronic oxidative stress that increases in cancer and in metabolic and neurodegenerative diseases. Modulation of endogenous cellular defense mechanisms represents an innovative approach to therapeutic intervention in diseases causing chronic tissue damage, such as in neurodegeneration. This article introduces the concept of hormesis and its applications to the field of neuroprotection. It is argued that the hormetic dose response provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their…
Citation impact
- FWCI
- 11.57
- Percentile
- 100%
- References
- 489
Authors
5Topics & keywords
- Hormesis
- Intervention (counseling)
- Cellular stress response
- Neuroscience
- Fight-or-flight response
- Medicine
- Psychology
- Biology
- Good health and well-being