FOXO3A genotype is strongly associated with human longevity
Kuakini Medical Center · Pacific Health Research and Education Institute · +4 more institutions
Abstract
Human longevity is a complex phenotype with a significant familial component, yet little is known about its genetic antecedents. Increasing evidence from animal models suggests that the insulin/IGF-1 signaling (IIS) pathway is an important, evolutionarily conserved biological pathway that influences aging and longevity. However, to date human data have been scarce. Studies have been hampered by small sample sizes, lack of precise phenotyping, and population stratification, among other challenges. Therefore, to more precisely assess potential genetic contributions to human longevity from genes linked to IIS signaling, we chose a large, homogeneous, long-lived population of men well-characterized for aging…
Citation impact
- FWCI
- 15.60
- Percentile
- 100%
- References
- 68
Authors
10- BJBradley J. WillcoxCorresponding
Kuakini Medical Center, Pacific Health Research and Education Institute
- TATimothy A. Donlon
University of Hawaiʻi at Mānoa, University of Hawaii System, Cancer Research Center, Pacific Health Research and Education Institute
- QHQimei He
Pacific Health Research and Education Institute
- RCRandi Chen
Kuakini Medical Center, Pacific Health Research and Education Institute
- JGJohn Grove
University of Hawaiʻi at Mānoa, University of Hawaii System, Cancer Research Center, Pacific Health Research and Education Institute
Topics & keywords
- Longevity
- Biology
- Phenotype
- Genetics
- Genotype
- Allele
- Population
- Gene
- Good health and well-being