Adverse Effect of Ventricular Pacing on Heart Failure and Atrial Fibrillation Among Patients With Normal Baseline QRS Duration in a Clinical Trial of Pacemaker Therapy for Sinus Node Dysfunction
Brigham and Women's Hospital · Mount Sinai Hospital · +6 more institutions
Abstract
Background— Dual-chamber (DDDR) pacing preserves AV synchrony and may reduce heart failure (HF) and atrial fibrillation (AF) compared with ventricular (VVIR) pacing in sinus node dysfunction (SND). However, DDDR pacing often results in prolonged QRS durations (QRSd) as the result of right ventricular stimulation, and ventricular desynchronization may result. The effect of pacing-induced ventricular desynchronization in patients with normal baseline QRSd is unknown. Methods and Results— Baseline QRSd was obtained from 12-lead ECGs before pacemaker implantation in MOST, a 2010-patient, 6-year, randomized trial of DDDR versus VVIR pacing in SND. Cumulative percent ventricular paced (Cum%VP) was determined from…
Citation impact
- FWCI
- 44.31
- Percentile
- 100%
- References
- 22
Authors
7- MOMichael O. SweeneyCorresponding
Brigham and Women's Hospital, Mount Sinai Hospital, Harvard University, University of Utah, Mount Sinai Medical Center, Duke Medical Center, Virginia Commonwealth University Medical Center, Jefferson College
- ASAnne S. Hellkamp
Brigham and Women's Hospital, Mount Sinai Hospital, Harvard University, University of Utah, Mount Sinai Medical Center, Duke Medical Center, Virginia Commonwealth University Medical Center, Jefferson College
- KAKenneth A. Ellenbogen
Brigham and Women's Hospital, Mount Sinai Hospital, Harvard University, University of Utah, Mount Sinai Medical Center, Duke Medical Center, Virginia Commonwealth University Medical Center, Jefferson College
- AJArnold J. Greenspon
Brigham and Women's Hospital, Mount Sinai Hospital, Harvard University, University of Utah, Mount Sinai Medical Center, Duke Medical Center, Virginia Commonwealth University Medical Center, Jefferson College
- RARoger A. Freedman
Brigham and Women's Hospital, Mount Sinai Hospital, Harvard University, University of Utah, Mount Sinai Medical Center, Duke Medical Center, Virginia Commonwealth University Medical Center, Jefferson College
Topics & keywords
- Medicine
- Cardiology
- Heart failure
- QRS complex
- Internal medicine
- Hazard ratio
- Atrial fibrillation
- Adverse effect
- Good health and well-being