Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
University of South Florida · Moffitt Cancer Center · +2 more institutions
Abstract
Accumulation of myeloid-derived suppressor cells (MDSCs) associated with inhibition of dendritic cell (DC) differentiation is one of the major immunological abnormalities in cancer and leads to suppression of antitumor immune responses. The molecular mechanism of this phenomenon remains unclear. We report here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in cancer. Mice lacking this protein mounted potent antitumor immune responses and rejected implanted tumors. This effect was reversed by administration of wild-type MDSCs from tumor-bearing mice to S100A9-null mice. Overexpression of S100A9 in cultured embryonic stem cells or transgenic mice inhibited the…
Citation impact
- FWCI
- 16.72
- Percentile
- 100%
- References
- 61
Authors
12- PCPingyan ChengCorresponding
University of South Florida, Moffitt Cancer Center
- CACesar A. Corzo
University of South Florida, Moffitt Cancer Center
- NLNoreen Luetteke
University of South Florida, Moffitt Cancer Center
- BYBin Yu
University of South Florida, Moffitt Cancer Center
- SNSrinivas Nagaraj
University of South Florida, Moffitt Cancer Center
Topics & keywords
- S100A9
- Myeloid-derived Suppressor Cell
- Immune system
- Biology
- Cancer research
- Myeloid
- Cancer cell
- Embryonic stem cell
- Good health and well-being