articleCell Death and DiseaseApr 17, 2014GOLD OA

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

ÁGÁgueda González‐RodríguezRMRafael MayoralNVNéstor Vázquez-AgraMPM. Pilar ValdecantosVPVirginia Pardo

Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas · Universidad Autónoma de Madrid · +8 more institutions

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Abstract

The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease (NAFLD) are not fully understood. In this study, we aimed to assess the relationship between endoplasmic reticulum (ER) stress and autophagy in human and mouse hepatocytes during NAFLD. ER stress and autophagy markers were analyzed in livers from patients with biopsy-proven non-alcoholic steatosis (NAS) or non-alcoholic steatohepatitis (NASH) compared with livers from subjects with histologically normal liver, in livers from mice fed with chow diet (CHD) compared with mice fed with high fat diet (HFD) or methionine-choline-deficient (MCD) diet and in primary and Huh7 human hepatocytes loaded with palmitic acid (PA). In…

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622
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23.29
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100%
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54
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Authors

16

Topics & keywords

Topics
Keywords
  • Unfolded protein response
  • Endoplasmic reticulum
  • Autophagy
  • CHOP
  • Endocrinology
  • Internal medicine
  • Steatohepatitis
  • Fatty liver
UN Sustainable Development Goals
  • Good health and well-being
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