Isolation of multipotent mesenchymal stem cells from umbilical cord blood
National Yang Ming Chiao Tung University · National Health Research Institutes · +4 more institutions
Abstract
It is well accepted that umbilical cord blood has been a source for hematopoietic stem cells. However, controversy exists as to whether cord blood can serve as a source of mesenchymal stem cells, which can differentiate into cells of different connective tissue lineages such as bone, cartilage, and fat, and little success has been reported in the literature about the isolation of such cells from cord blood. Here we report a novel method to obtain single cell-derived, clonally expanded mesenchymal stem cells that are of multilineage differentiation potential by negative immunoselection and limiting dilution. The immunophenotype of these clonally expanded cells is consistent with that reported for bone marrow…
Citation impact
- FWCI
- 17.79
- Percentile
- 100%
- References
- 21
Authors
6- OKOscar K. LeeCorresponding
National Yang Ming Chiao Tung University, National Health Research Institutes, Taipei Veterans General Hospital, National Yang Ming University Hospital, National Yang Ming Chiao Tung University, National Taipei University
- TKTom K. Kuo
National Yang Ming Chiao Tung University, National Health Research Institutes, Taipei Veterans General Hospital, National Yang Ming University Hospital, National Yang Ming Chiao Tung University, National Taipei University
- WCWei‐Ming Chen
National Yang Ming Chiao Tung University, National Health Research Institutes, Taipei Veterans General Hospital, National Yang Ming University Hospital, National Yang Ming Chiao Tung University, National Taipei University
- KLKuan‐Der Lee
National Yang Ming Chiao Tung University, National Health Research Institutes, Taipei Veterans General Hospital, National Yang Ming University Hospital, National Yang Ming Chiao Tung University, National Taipei University
- SHShie‐Liang Hsieh
National Yang Ming Chiao Tung University, National Health Research Institutes, Taipei Veterans General Hospital, National Yang Ming University Hospital, National Yang Ming Chiao Tung University, National Taipei University
Topics & keywords
- Mesenchymal stem cell
- Umbilical cord
- Cord lining
- Stem cell
- Multipotent Stem Cell
- Biology
- Adult stem cell
- Immunology