SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
University of Pittsburgh Medical Center · University of California, Los Angeles
Abstract
Reduced caloric intake decreases arterial blood pressure in healthy individuals and improves endothelium-dependent vasodilation in obese and overweight individuals. The SIRT1 protein deacetylase mediates many of the effects of calorie restriction (CR) on organismal lifespan and metabolic pathways. However, the role of SIRT1 in regulating endothelium-dependent vasomotor tone is not known. Here we show that SIRT1 promotes endothelium-dependent vasodilation by targeting endothelial nitric oxide synthase (eNOS) for deacetylation. SIRT1 and eNOS colocalize and coprecipitate in endothelial cells, and SIRT1 deacetylates eNOS, stimulating eNOS activity and increasing endothelial nitric oxide (NO). SIRT1-induced…
Citation impact
- FWCI
- 18.98
- Percentile
- 100%
- References
- 23
Authors
9- IMIlwola Mattagajasingh
University of Pittsburgh Medical Center
- CKCuk‐Seong Kim
University of California, Los Angeles, University of Pittsburgh Medical Center
- ANAsma Naqvi
University of California, Los Angeles, University of Pittsburgh Medical Center
- TYTohru Yamamori
University of California, Los Angeles, University of Pittsburgh Medical Center
- TATimothy A. Hoffman
University of California, Los Angeles, University of Pittsburgh Medical Center
Topics & keywords
- Enos
- Endothelium
- Vasodilation
- Nitric oxide
- Internal medicine
- Endocrinology
- Nitric Oxide Synthase Type III
- Endothelial dysfunction