Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database

Post-translational modifications (PTMs) broadly contribute to the recent explosion of proteomic data and possess a complexity surpassing that of protein design. PTMs are the chemical modification of a protein after its translation, and have wide effects broadening its range of functionality. Based on previous estimates, it is widely believed that more than half of proteins are glycoproteins. Whereas mutations can only occur once per position, different forms of post-translational modifications may occur in tandem. With the number and abundances of modifications constantly being discovered, there is no method to readily assess their relative levels. Here we report the relative abundances of each PTM found…

• NS
  National Science Foundation

  Awards: 0646086, DGE-0646086
• PU
  Princeton University
• NI
  National Institutes of Health
• UN
  U.S. National Library of Medicine