Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts

Okino, Tomotaka; Hoashi, Yasutaka; Takemoto, Yoshiji

doi:10.1021/ja036972z

articleJournal of the American Chemical SocietySep 30, 2003Closed access

Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts

TOTomotaka Okino YHYasutaka Hoashi YTYoshiji Takemoto

Kyoto University

PubMed

Indexed incrossrefpubmed

Abstract

Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).

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Topics & keywords

Topics

Keywords

Bifunctional
Chemistry
Enantioselective synthesis
Michael reaction
Thiourea
Adduct
Organocatalysis
Organic chemistry

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