Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case‐control study
Georgetown University · Georgetown University Medical Center · +9 more institutions
Abstract
Proteins pathogenic in Alzheimer's disease (AD) were extracted from neurally derived blood exosomes and quantified to develop biomarkers for the staging of sporadic AD.
Blood exosomes obtained at one time-point from patients with AD (n = 57) or frontotemporal dementia (FTD) (n = 16), and at two time-points from others (n = 24) when cognitively normal and 1 to 10 years later when diagnosed with AD were enriched for neural sources by immunoabsorption. AD-pathogenic exosomal proteins were extracted and quantified by enzyme-linked immunosorbent assays.
Citation impact
- FWCI
- 18.07
- Percentile
- 100%
- References
- 31
Authors
11- MSMassimo S. Fiandaca
Georgetown University, Georgetown University Medical Center, Zero to Three
- DKDimitrios Kapogiannis
Zero to Three, Institute on Aging, National Institute on Aging
- MMMark Mapstone
Zero to Three, University of Rochester
- ALAdam L. Boxer
University of California, San Francisco, University of California San Francisco Medical Center
- EEErez Eitan
Institute on Aging, National Institute on Aging
Topics & keywords
- Microvesicles
- Identification (biology)
- Disease
- Alzheimer's disease
- Medicine
- Immunology
- Neuroscience
- Biology
- Reduced inequalities