Cellular senescence and tumor suppressor gene p16
University of California, Los Angeles · University School · +3 more institutions
Abstract
Cellular senescence is an irreversible arrest of cell growth. Biochemical and morphological changes occur during cellular senescence, including the formation of a unique cellular morphology such as flattened cytoplasm. Function of mitochondria, endoplasmic reticulum and lysosomes are affected resulting in the inhibition of lysosomal and proteosomal pathways. Cellular senescence can be triggered by a number of factors including, aging, DNA damage, oncogene activation and oxidative stress. While the molecular mechanism of senescence involves p16 and p53 tumor suppressor genes and telomere shortening, this review is focused on the mechanism of p16 control. The p16-mediated senescence acts through the…
Citation impact
- FWCI
- 11.92
- Percentile
- 100%
- References
- 126
Authors
3- HRHani Rayess
University of California, Los Angeles, University School, VA Greater Los Angeles Healthcare System, Case Western Reserve University
- MBMarilene B. Wang
University of California, Los Angeles, VA Greater Los Angeles Healthcare System
- ESEri S. SrivatsanCorresponding
University of California, Los Angeles, In-Q-Tel, VA Greater Los Angeles Healthcare System
Topics & keywords
- Cell biology
- Biology
- Senescence
- Retinoblastoma protein
- E2F1
- Transcription factor
- Repressor
- Cell cycle