reviewJournal of Cerebral Blood Flow & MetabolismAug 29, 2012BRONZE OA

Drug Transport across the Blood–Brain Barrier

WMWilliam M. Pardridge
PubMed
Indexed incrossrefpubmed

Abstract

The blood-brain barrier (BBB) prevents the brain uptake of most pharmaceuticals. This property arises from the epithelial-like tight junctions within the brain capillary endothelium. The BBB is anatomically and functionally distinct from the blood-cerebrospinal fluid barrier at the choroid plexus. Certain small molecule drugs may cross the BBB via lipid-mediated free diffusion, providing the drug has a molecular weight

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Authors

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Topics & keywords

Topics
Keywords
  • Blood–brain barrier
  • Choroid plexus
  • Drug delivery
  • Chemistry
  • Tight junction
  • Nanomedicine
  • Drug carrier
  • Drug
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