Platelets guide the formation of early metastatic niches
St. Jude Children's Research Hospital · Howard Hughes Medical Institute · +1 more institution
Abstract
During metastasis, host cells are recruited to disseminated tumor cells to form specialized microenvironments ("niches") that promote metastatic progression, but the mechanisms guiding the assembly of these niches are largely unknown. Tumor cells may autonomously recruit host cells or, alternatively, host cell-to-host cell interactions may guide the formation of these prometastatic microenvironments. Here, we show that platelet-derived rather than tumor cell-derived signals are required for the rapid recruitment of granulocytes to tumor cells to form "early metastatic niches." Granulocyte recruitment relies on the secretion of CXCL5 and CXCL7 chemokines by platelets upon contact with tumor cells. Blockade of…
Citation impact
- FWCI
- 15.07
- Percentile
- 100%
- References
- 60
Authors
3- MLMyriam LabelleCorresponding
St. Jude Children's Research Hospital, Howard Hughes Medical Institute, Massachusetts Institute of Technology
- SBShahinoor Begum
Howard Hughes Medical Institute, Massachusetts Institute of Technology
- RORichard O. Hynes
Howard Hughes Medical Institute, Massachusetts Institute of Technology
Topics & keywords
- Niche
- Biology
- Metastasis
- Ecological niche
- Platelet
- Tumor microenvironment
- CXCL5
- Immunology
- Good health and well-being
Funding
- HHHoward Hughes Medical InstituteAward: P30-CA14051
- MIMassachusetts Institute of TechnologyAward: P30-CA14051
- ALAmerican Lebanese Syrian Associated Charities
- KIKoch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyAwards: P30-CA14051, Grant P30-CA14051
- LCLudwig Center for Molecular Oncology
- LCLudwig Center at Harvard
- NCNational Cancer InstituteAwards: U54 CA163109, P30-CA14051, CA14051, Grant P30-CA14051