SNPassoc: an R package to perform whole genome association studies
Institut d'Investigació Biomédica de Bellvitge · Institut Català d'Oncologia · +1 more institution
Abstract
UNLABELLED: The popularization of large-scale genotyping projects has led to the widespread adoption of genetic association studies as the tool of choice in the search for single nucleotide polymorphisms (SNPs) underlying susceptibility to complex diseases. Although the analysis of individual SNPs is a relatively trivial task, when the number is large and multiple genetic models need to be explored it becomes necessary a tool to automate the analyses. In order to address this issue, we developed SNPassoc, an R package to carry out most common analyses in whole genome association studies. These analyses include descriptive statistics and exploratory analysis of missing values, calculation of Hardy-Weinberg…
Citation impact
- FWCI
- 21.09
- Percentile
- 100%
- References
- 10
Authors
7- JRJuan R. GonzálezCorresponding
Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centre for Genomic Regulation
- LALluı́s Armengol
Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centre for Genomic Regulation
- XSXavier Solé
Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centre for Genomic Regulation
- EGElisabet Guinó
Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centre for Genomic Regulation
- JMJosep M. Mercader
Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centre for Genomic Regulation
Topics & keywords
- Genetic association
- Single-nucleotide polymorphism
- R package
- Genome-wide association study
- Computer science
- Genotyping
- Epistasis
- Haplotype