Toll-like receptor 7 (TLR7)–driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity
Howard Hughes Medical Institute · National Jewish Health · +3 more institutions
Abstract
Females are more susceptible than males to many autoimmune diseases. The processes causing this phenomenon are incompletely understood. Here, we demonstrate that aged female mice acquire a previously uncharacterized population of B cells that we call age-associated B cells (ABCs) and that these cells express integrin α(X) chain (CD11c). This unexpected population also appears in young lupus-prone mice. On stimulation, CD11c(+) B cells, both from autoimmune-prone and healthy strains of mice, secrete autoantibodies, and depletion of these cells in vivo leads to reduction of autoreactive antibodies, suggesting that the cells might have a direct role in the development of autoimmunity. We have explored factors…
Citation impact
- FWCI
- 8.47
- Percentile
- 100%
- References
- 39
Authors
7- AVAnatoly V. RubtsovCorresponding
Howard Hughes Medical Institute, National Jewish Health, University of Colorado Health, University of Colorado Denver
- KRKira Rubtsova
Howard Hughes Medical Institute, National Jewish Health, University of Colorado Health, University of Colorado Denver
- AFAryeh Fischer
National Jewish Health, University of Colorado Denver
- RTRichard T. Meehan
National Jewish Health, University of Colorado Denver
- JZJoann Zell Gillis
National Jewish Health, University of Colorado Denver
Topics & keywords
- Immunology
- Autoimmunity
- Biology
- CD11c
- Population
- TLR7
- Autoantibody
- B cell
- Good health and well-being