reviewChemical Society ReviewsOct 13, 2014Closed access

Recent advances in C–S bond formation via C–H bond functionalization and decarboxylation

Hangzhou Normal University · Hangzhou Academy of Agricultural Sciences · +5 more institutions

PubMed
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Abstract

The development of mild and general methods for C-S bond formation has received significant attention because the C-S bond is indispensable in many important biological and pharmaceutical compounds. Early examples for the synthesis of C-S bonds are generally limited to the condensation reaction between a metal thiolate and an organic halide. Recent chemical approaches for C-S bond formation, based upon direct C-H bond functionalization and decarboxylative reactions, not only provide new insights into the mechanistic understanding of C-S coupling reactions but also allow the synthesis of sulfur-containing compounds from more effective synthetic routes with high atom economy. This review intends to explore…

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