Sir2 mediates longevity in the fly through a pathway related to calorie restriction

Calorie restriction can extend life span in a variety of species including mammals, flies, nematodes, and yeast. Despite the importance of this nearly universal effect, little is understood about the molecular mechanisms that mediate the life-span-extending effect of calorie restriction in metazoans. Sir2 is known to be involved in life span determination and calorie restriction in yeast mother cells. In nematodes increased Sir2 can extend life span, but a direct link to calorie restriction has not been demonstrated. We now report that Sir2 is directly involved in the calorie-restriction life-span-extending pathway in Drosophila. We demonstrate that an increase in Drosophila Sir2 (dSir2) extends life span,…

• EM
  Ellison Medical Foundation
• PA
  Patrick and Catherine Weldon Donaghue Medical Research Foundation
• YU
  Yale University
• HF
  Hospital for Sick Children
• SU
  Stockholms Universitet
• NI
  National Institutes of Health