A Computational Tool for Quantitative Analysis of Vascular Networks
National Cancer Institute · Babraham Institute · +1 more institution
Abstract
Angiogenesis is the generation of mature vascular networks from pre-existing vessels. Angiogenesis is crucial during the organism' development, for wound healing and for the female reproductive cycle. Several murine experimental systems are well suited for studying developmental and pathological angiogenesis. They include the embryonic hindbrain, the post-natal retina and allantois explants. In these systems vascular networks are visualised by appropriate staining procedures followed by microscopical analysis. Nevertheless, quantitative assessment of angiogenesis is hampered by the lack of readily available, standardized metrics and software analysis tools. Non-automated protocols are being used widely and…
Citation impact
- FWCI
- 5.19
- Percentile
- 100%
- References
- 31
Authors
4Topics & keywords
- Angiogenesis
- Computer science
- Vascular network
- Sprouting angiogenesis
- Biology
- Biomedical engineering
- Neovascularization
- Bioinformatics
- Decent work and economic growth