Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa
University of Illinois Urbana-Champaign · University of Michigan · +1 more institution
Abstract
Equilibrium models of isolation by distance predict an increase in genetic differentiation with geographic distance. Here we find a linear relationship between genetic and geographic distance in a worldwide sample of human populations, with major deviations from the fitted line explicable by admixture or extreme isolation. A close relationship is shown to exist between the correlation of geographic distance and genetic differentiation (as measured by F(ST)) and the geographic pattern of heterozygosity across populations. Considering a worldwide set of geographic locations as possible sources of the human expansion, we find that heterozygosities in the globally distributed populations of the data set are best…
Citation impact
- FWCI
- 22.79
- Percentile
- 100%
- References
- 36
Authors
6- SRSohini RamachandranCorresponding
University of Illinois Urbana-Champaign, University of Michigan, Stanford University
- ODOmkar Deshpande
University of Illinois Urbana-Champaign, University of Michigan, Stanford University
- CCCharles C. Roseman
University of Illinois Urbana-Champaign, University of Michigan, Stanford University
- NANoah A. Rosenberg
University of Illinois Urbana-Champaign, University of Michigan, Stanford University
- MWMarcus W. Feldman
University of Illinois Urbana-Champaign, University of Michigan, Stanford University
Topics & keywords
- Geographical distance
- Isolation by distance
- Biological dispersal
- Genetic drift
- Genetic distance
- Genetic diversity
- Founder effect
- Selection (genetic algorithm)