Promotion of Tissue Inflammation by the Immune Receptor Tim-3 Expressed on Innate Immune Cells
Brigham and Women's Hospital · University of Pittsburgh · +4 more institutions
Abstract
CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1…
Citation impact
- FWCI
- 8.57
- Percentile
- 100%
- References
- 20
Authors
14- ACAna C. AndersonCorresponding
Brigham and Women's Hospital, University of Pittsburgh, Kagawa University, Takamatsu University, The Neurological Institute, New York College of Health Professions
- DEDavid E. Anderson
Brigham and Women's Hospital, University of Pittsburgh, Kagawa University, Takamatsu University, The Neurological Institute, New York College of Health Professions
- LBLisa Bregoli
Brigham and Women's Hospital, University of Pittsburgh, Kagawa University, Takamatsu University, The Neurological Institute, New York College of Health Professions
- WDWilliam D. Hastings
Brigham and Women's Hospital, University of Pittsburgh, Kagawa University, Takamatsu University, The Neurological Institute, New York College of Health Professions
- NKNasim Kassam
Brigham and Women's Hospital, University of Pittsburgh, Kagawa University, Takamatsu University, The Neurological Institute, New York College of Health Professions
Topics & keywords
- Innate immune system
- Immune system
- Biology
- Innate lymphoid cell
- Acquired immune system
- Inflammation
- Immunology
- CCL18
- Good health and well-being