Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
La Jolla Institute for Immunology · Boston Children's Hospital · +2 more institutions
Abstract
The Ten-Eleven-Translocation 2 (TET2) gene encodes a member of TET family enzymes that alters the epigenetic status of DNA by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC). Somatic loss-of-function mutations of TET2 are frequently observed in patients with diverse myeloid malignancies, including myelodysplastic syndromes, myeloproliferative neoplasms, and chronic myelomonocytic leukemia. By analyzing mice with targeted disruption of the Tet2 catalytic domain, we show here that Tet2 is a critical regulator of self-renewal and differentiation of hematopoietic stem cells (HSCs). Tet2 deficiency led to decreased genomic levels of 5hmC and augmented the size of the hematopoietic stem/progenitor cell…
Citation impact
- FWCI
- 17.29
- Percentile
- 100%
- References
- 41
Authors
10- MKMyunggon KoCorresponding
La Jolla Institute for Immunology
- HSHozefa S. Bandukwala
Boston Children's Hospital, Harvard University
- JAJungeun An
La Jolla Institute for Immunology
- EDEdward D. Lamperti
Boston Children's Hospital, Harvard University
- ECElizabeth C. Thompson
Boston Children's Hospital, Harvard University
Topics & keywords
- Biology
- Haematopoiesis
- Stem cell
- Myeloid
- Progenitor cell
- Epigenetics
- Cell biology
- Lymphopoiesis