Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors
Harvard University · University of Cyprus · +3 more institutions
Abstract
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and blood vessels. Compression of lymphatic vessels elevates interstitial fluid pressure, whereas compression of blood vessels reduces blood flow. Reduced blood flow, in turn, leads to hypoxia, which promotes tumor progression, immunosuppression, inflammation, invasion, and metastasis and lowers the efficacy of chemo-, radio-, and immunotherapies. Thus, strategies designed to alleviate solid stress have the potential to improve cancer treatment. However, a lack of…
Citation impact
- FWCI
- 15.35
- Percentile
- 100%
- References
- 68
Authors
12- TSTriantafyllos StylianopoulosCorresponding
Harvard University, University of Cyprus, Massachusetts General Hospital
- JDJohn D. Martin
Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology
- VPVikash P. Chauhan
Harvard University, Massachusetts General Hospital
- SRSaloni R. Jain
Harvard University, Massachusetts General Hospital, Massachusetts Institute of Technology
- BDBenjamin Diop-Frimpong
Harvard University, Massachusetts General Hospital, Harvard–MIT Division of Health Sciences and Technology
Topics & keywords
- Lymphatic system
- Perfusion
- Blood flow
- Cancer research
- Medicine
- Solid tumor
- Pathology
- Cancer
- Good health and well-being