Gut Microbes and the Brain: Paradigm Shift in Neuroscience
University of California, Los Angeles · Neurobehavioral Systems · +5 more institutions
Abstract
The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. A growing body of preclinical literature has demonstrated bidirectional signaling between the brain and the gut microbiome, involving multiple neurocrine and endocrine signaling mechanisms. While psychological and physical stressors can affect the composition and metabolic activity of the gut microbiota, experimental changes to the gut microbiome can affect emotional behavior and related brain systems. These findings have resulted in speculation that alterations in the gut microbiome may play a pathophysiological role in human…
Citation impact
- FWCI
- 28.31
- Percentile
- 100%
- References
- 74
Authors
5- EAEmeran A. MayerCorresponding
University of California, Los Angeles, Neurobehavioral Systems
- RKRob Knight
Howard Hughes Medical Institute, University of Colorado Boulder
- SKSarkis K. Mazmanian
California Institute of Technology
- JFJohn F. Cryan
University College Cork
- KTKirsten Tillisch
University of California, Los Angeles, VA Greater Los Angeles Healthcare System
Topics & keywords
- Microbiome
- Neuroscience
- Gut–brain axis
- Gut microbiome
- Autism
- Disease
- Population
- Anxiety
- Good health and well-being
Funding
- ASAutism Speaks
- SFSimons Foundation Autism Research Initiative
- NINational Institutes of HealthAwards: R01 DK048351, DK048351, P30 DK041301, MH100556, DK041301
- NINational Institute of Mental Health
- NINational Institute of Diabetes and Digestive and Kidney DiseasesAwards: DK048351, P30 DK041301, DK041301, R01 DK048351