Precuneus Is a Functional Core of the Default-Mode Network

Efforts to understand the functional architecture of the brain have consistently identified multiple overlapping large-scale neural networks that are observable across multiple states. Despite the ubiquity of these networks, it remains unclear how regions within these large-scale neural networks interact to orchestrate behavior. Here, we collected functional magnetic resonance imaging data from 188 human subjects who engaged in three cognitive tasks and a resting-state scan. Using multiple tasks and a large sample allowed us to use split-sample validations to test for replication of results. We parceled the task-rest pairs into functional networks using a probabilistic spatial independent components analysis.…

• NI
  National Institutes of Health

  Award: NIMH RC1-88680
• DI
  Duke Institute for Brain Sciences, Duke University
• NI
  National Institute of Mental Health