Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · Johns Hopkins University · +4 more institutions
Abstract
Continued androgen receptor (AR) signaling is an established mechanism underlying castration-resistant prostate cancer (CRPC), and suppression of androgen receptor signaling remains a therapeutic goal of CRPC therapy. Constitutively active androgen receptor splice variants (AR-Vs) lack the androgen receptor ligand-binding domain (AR-LBD), the intended target of androgen deprivation therapies including CRPC therapies such as abiraterone and MDV3100. While the canonical full-length androgen receptor (AR-FL) and AR-Vs are both increased in CRPCs, their expression regulation, associated transcriptional programs, and functional relationships have not been dissected. In this study, we show that suppression of…
Citation impact
- FWCI
- 42.58
- Percentile
- 100%
- References
- 20
Authors
12- RHRong Hu
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Johns Hopkins University, University of Washington, Fred Hutch Cancer Center, Cancer Research Center, University of Glasgow
- CLChangxue Lu
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Johns Hopkins University, University of Washington, Fred Hutch Cancer Center, Cancer Research Center, University of Glasgow
- EAElahe A. Mostaghel
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Johns Hopkins University, University of Washington, Fred Hutch Cancer Center, Cancer Research Center, University of Glasgow
- SYSrinivasan Yegnasubramanian
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Johns Hopkins University, University of Washington, Fred Hutch Cancer Center, Cancer Research Center, University of Glasgow
- MÖMeltem Ö. Gürel
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa, Johns Hopkins University, University of Washington, Fred Hutch Cancer Center, Cancer Research Center, University of Glasgow
Topics & keywords
- Prostate cancer
- splice
- Androgen receptor
- Castration
- Androgen
- Medicine
- Alternative splicing
- Cancer
- Good health and well-being