Hippocampectomy disrupts trace eye-blink conditioning in rabbits.
Northwestern University · Institute of Molecular and Cell Biology · +1 more institution
Abstract
The role of the hippocampus (HFC) in trace eye-blink conditioning was evaluated using a 100-ms tone conditioned stimulus (CS), a 300- or 500-ms trace interval, and a 150-ms air puff unconditioned stimulus (UCS). Rabbits received complete hippocampectomy (dorsal & ventral), sham lesions, or neocortical lesions. Hippocampectomy produced differential effects in relation to the trace interval used. With a 300-ms trace interval, HPC-lesioned Ss showed profound resistance to extinction after acquisition. With a 500-ms trace interval, HPC-lesioned Ss did not learn the task (only 22% conditioned responses (CRs) after 25 sessions, whereas controls showed >80% after 10 sessions), and on the few trials in which a CR…
Citation impact
- FWCI
- 10.58
- Percentile
- 100%
- References
- 43
Authors
3- JRJames R. MoyerCorresponding
Northwestern University, Institute of Molecular and Cell Biology, Institute of Structural and Molecular Biology
- RARichard A. Deyo
Northwestern University, Institute of Molecular and Cell Biology, Institute of Structural and Molecular Biology
- JFJohn F. Disterhoft
Institute of Molecular and Cell Biology, Institute of Structural and Molecular Biology
Topics & keywords
- Classical conditioning
- Conditioning
- Psychology
- Neuroscience
- Extinction (optical mineralogy)
- Stimulus (psychology)
- Associative learning
- Unconditioned stimulus