Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis
Imperial College London · St Mary's Hospital · +6 more institutions
Abstract
Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver in the world. Given that the burden of chronic liver disease is expected to rise owing to increasing rates of alcoholism, hepatitis B and C prevalence and obesity-related fatty liver disease, it is expected that the incidence of HCC will also increase in the foreseeable future. This article summarizes the international epidemiology, the risk factors and the pathogenesis of HCC, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance.
Citation impact
- FWCI
- 22.79
- Percentile
- 100%
- References
- 138
Authors
5- AGAsmaa Gomaa
Imperial College London, St Mary's Hospital
- SAShahid A. KhanCorresponding
Engineering and Physical Sciences Research Council, Eli and Edythe Broad Foundation, University of British Columbia, Pfizer (United Kingdom), Imperial College London, Menoufia University, St Mary's Hospital, GlaxoSmithKline (United Kingdom)
- MBMireille B. Toledano
University of British Columbia, St Mary's Hospital, Menoufia University, GlaxoSmithKline (United Kingdom), Engineering and Physical Sciences Research Council, Imperial College London, Eli and Edythe Broad Foundation, Pfizer (United Kingdom)
- IWImam Waked
GlaxoSmithKline (United Kingdom), Eli and Edythe Broad Foundation, Engineering and Physical Sciences Research Council, Menoufia University, Imperial College London, Pfizer (United Kingdom), St Mary's Hospital, University of British Columbia
- SDSimon D. Taylor‐Robinson
Pfizer (United Kingdom), Imperial College London, Engineering and Physical Sciences Research Council, Menoufia University, Eli and Edythe Broad Foundation, GlaxoSmithKline (United Kingdom), St Mary's Hospital, University of British Columbia
Topics & keywords
- Hepatocellular carcinoma
- Medicine
- Epidemiology
- Fatty liver
- Pathogenesis
- Incidence (geometry)
- Liver cancer
- Hepatitis B
- Good health and well-being