Role of NRF2 in Protection Against Hyperoxic Lung Injury in Mice
Johns Hopkins University · University of Tsukuba
Abstract
NRF2 is a transcription factor important in the protection against carcinogenesis and oxidative stress through antioxidant response element (ARE)-mediated transcriptional activation of several phase 2 detoxifying and antioxidant enzymes. This study was designed to determine the role of NRF2 in the pathogenesis of hyperoxic lung injury by comparing pulmonary responses to 95-98% oxygen between mice with site-directed mutation of the gene for NRF2 (Nrf2-/-) and wild-type mice (Nrf2+/+). Pulmonary hyperpermeability, macrophage inflammation, and epithelial injury in Nrf2-/- mice were 7.6-fold, 47%, and 43% greater, respectively, compared with Nrf2+/+ mice after 72 h hyperoxia exposure. Hyperoxia markedly elevated…
Citation impact
- FWCI
- 10.35
- Percentile
- 100%
- References
- 43
Authors
7- HCHye‐Youn ChoCorresponding
Johns Hopkins University, University of Tsukuba
- AJAnne Jedlicka
Johns Hopkins University, University of Tsukuba
- SPSekhar P. Reddy
Johns Hopkins University, University of Tsukuba
- TWThomas W. Kensler
Johns Hopkins University, University of Tsukuba
- MYMasayuki Yamamoto
Johns Hopkins University, University of Tsukuba
Topics & keywords
- Hyperoxia
- Glutathione
- Oxidative stress
- Glutathione peroxidase
- Antioxidant
- Molecular biology
- Chemistry
- Lung
- Good health and well-being