Quorum-sensing regulators control virulence gene expression in Vibrio cholerae

The production of virulence factors including cholera toxin and the toxin-coregulated pilus in the human pathogen Vibrio cholerae is strongly influenced by environmental conditions. The well-characterized ToxR signal transduction cascade is responsible for sensing and integrating the environmental information and controlling the virulence regulon. We show here that, in addition to the known components of the ToxR signaling circuit, quorum-sensing regulators are involved in regulation of V. cholerae virulence. We focused on the regulators LuxO and HapR because homologues of these two proteins control quorum sensing in the closely related luminous marine bacterium Vibrio harveyi. Using an infant mouse model, we…

• NS
  National Science Foundation

  Award: 0094447
• DR
  Damon Runyon Cancer Research Foundation
• NI
  National Institutes of Health
• OO
  Office of Naval Research

  Award: N00014