Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice
Conselho Nacional de Desenvolvimento Científico e Tecnológico · Universidade Federal do Rio de Janeiro · +3 more institutions
Abstract
<b><i>Background/Aims:</i></b> Anxious responses are evolutionarily adaptive, but excessive fear can become disabling and lead to anxiety disorders. Translational models of anxiety might be useful sources for understanding the neurobiology of fear and anxiety and can contribute to future proposals of therapeutic intervention for the disorders studied. Brain-derived neurotrophic factor (BDNF), which is known for its importance on neuroplasticity and contextual memory, has emerged as a relevant element for emotional memory. Recent studies show that the Val<sup>66</sup>Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several…
Citation impact
- FWCI
- 123.01
- Percentile
- 100%
- References
- 195
Authors
7- ACAnna Claudia Domingos da Silveira da LuzCorresponding
Conselho Nacional de Desenvolvimento Científico e Tecnológico
- GPGisele Pereira Dias
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Universidade Federal do Rio de Janeiro, King's College London, Czech Academy of Sciences, Institute of Biophysics
- MCMário Cesar do Nascimento Bevilaqua
Conselho Nacional de Desenvolvimento Científico e Tecnológico, Universidade Castelo Branco
- GCGraham Cocks
King's College London
- PGP.F. Gardino
Universidade Federal do Rio de Janeiro, Czech Academy of Sciences, Institute of Biophysics
Topics & keywords
- Neurotrophic factors
- Neuroscience
- Neurotrophin
- Long-term potentiation
- Schaffer collateral
- Brain-derived neurotrophic factor
- Synaptic plasticity
- Nerve growth factor
- Good health and well-being