Hepatic inflammation and fibrosis: Functional links and key pathways
University of California San Diego · Columbia University
Abstract
Inflammation is one of the most characteristic features of chronic liver disease of viral, alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease stages and associated with the development of fibrosis, cirrhosis, and hepatocellular carcinoma. In the past decade, numerous studies have contributed to improved understanding of the links between hepatic inflammation and fibrosis. Here, we review mechanisms that link inflammation with the development of liver fibrosis, focusing on the role of inflammatory mediators in hepatic stellate cell (HSC) activation and HSC survival during fibrogenesis and fibrosis regression. We will summarize the contributions of different inflammatory…
Citation impact
- FWCI
- 34.51
- Percentile
- 100%
- References
- 113
Authors
2Topics & keywords
- Inflammation
- Key (lock)
- Fibrosis
- Medicine
- Computer science
- Pathology
- Internal medicine
- Computer security
- Good health and well-being