The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin
University of Fukui · Centre National de la Recherche Scientifique · +5 more institutions
Abstract
A number of large noncoding RNAs (ncRNAs) epigenetically silence genes through unknown mechanisms. The Air ncRNA is imprinted--monoallelically expressed from the paternal allele. Air is required for allele-specific silencing of the cis-linked Slc22a3, Slc22a2, and Igf2r genes in mouse placenta. We show that Air interacts with the Slc22a3 promoter chromatin and the H3K9 histone methyltransferase G9a in placenta. Air accumulates at the Slc22a3 promoter in correlation with localized H3K9 methylation and transcriptional repression. Genetic ablation of G9a results in nonimprinted, biallelic transcription of Slc22a3. Truncated Air fails to accumulate at the Slc22a3 promoter, which results in reduced G9a recruitment…
Citation impact
- FWCI
- 21.87
- Percentile
- 100%
- References
- 19
Authors
7- TNTakashi NaganoCorresponding
University of Fukui, Centre National de la Recherche Scientifique, Babraham Institute, Université de Montpellier, University of Cambridge, Institut de Génétique Moléculaire de Montpellier, CeMM Research Center for Molecular Medicine
- JAJennifer A. Mitchell
University of Fukui, Centre National de la Recherche Scientifique, Babraham Institute, Université de Montpellier, University of Cambridge, Institut de Génétique Moléculaire de Montpellier, CeMM Research Center for Molecular Medicine
- LALionel A. Sanz
University of Fukui, Centre National de la Recherche Scientifique, Babraham Institute, Université de Montpellier, University of Cambridge, Institut de Génétique Moléculaire de Montpellier, CeMM Research Center for Molecular Medicine
- FMFlorian M. Pauler
University of Fukui, Centre National de la Recherche Scientifique, Babraham Institute, Université de Montpellier, University of Cambridge, Institut de Génétique Moléculaire de Montpellier, CeMM Research Center for Molecular Medicine
- ACAnne C. Ferguson‐Smith
University of Fukui, Centre National de la Recherche Scientifique, Babraham Institute, Université de Montpellier, University of Cambridge, Institut de Génétique Moléculaire de Montpellier, CeMM Research Center for Molecular Medicine
Topics & keywords
- Chromatin
- Transcription (linguistics)
- Biology
- Non-coding RNA
- RNA
- Genetics
- Long non-coding RNA
- Cell biology