reviewCold Spring Harbor Perspectives in BiologySep 1, 2011BRONZE OA

Integrins in Cell Migration

AHAnna HuttenlocherARAlan Rick Horwitz

University of Wisconsin–Madison · University of Virginia

PubMed
Indexed incrossrefpubmed

Abstract

Integrin-based adhesion has served as a model for studying the central role of adhesion in migration. In this article, we outline modes of migration, both integrin-dependent and -independent in vitro and in vivo. We next discuss the roles of adhesion contacts as signaling centers and linkages between the ECM and actin that allows adhesions to serve as traction sites. This includes signaling complexes that regulate migration and the interplay among adhesion, signaling, and pliability of the substratum. Finally, we address mechanisms of adhesion assembly and disassembly and the role of adhesion in cellular polarity.

Citation impact

758
total citations
FWCI
—
Percentile
—
References
218
Citations per year

Authors

2

Topics & keywords

Topics
Keywords
  • Integrin
  • Cell biology
  • Biology
  • Adhesion
  • Cell adhesion
  • Cell migration
  • Actin
  • Cell polarity
UN Sustainable Development Goals
  • Reduced inequalities
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Funding