reviewJournal of Clinical InvestigationFeb 17, 2015BRONZE OA

Gut/brain axis and the microbiota

EAEmeran A. MayerKTKirsten TillischAGArpana Gupta

Czech Academy of Sciences, Institute of Physiology · University of California, Los Angeles

PubMed
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Abstract

Tremendous progress has been made in characterizing the bidirectional interactions between the central nervous system, the enteric nervous system, and the gastrointestinal tract. A series of provocative preclinical studies have suggested a prominent role for the gut microbiota in these gut-brain interactions. Based on studies using rodents raised in a germ-free environment, the gut microbiota appears to influence the development of emotional behavior, stress- and pain-modulation systems, and brain neurotransmitter systems. Additionally, microbiota perturbations by probiotics and antibiotics exert modulatory effects on some of these measures in adult animals. Current evidence suggests that multiple mechanisms,…

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1,436
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100%
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Authors

3

Topics & keywords

Topics
Keywords
  • Gut–brain axis
  • Gut flora
  • Irritable bowel syndrome
  • Neuroscience
  • Enteric nervous system
  • Central nervous system
  • Biology
  • Endocrine system
UN Sustainable Development Goals
  • Good health and well-being
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