Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
Harvard University · Yale University · +3 more institutions
Abstract
The sirtuins are a family of highly conserved NAD(+)-dependent deacetylases that act as cellular sensors to detect energy availability and modulate metabolic processes. Two sirtuins that are central to the control of metabolic processes are mammalian sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3), which are localized to the nucleus and mitochondria, respectively. Both are activated by high NAD(+) levels, a condition caused by low cellular energy status. By deacetylating a variety of proteins that induce catabolic processes while inhibiting anabolic processes, SIRT1 and SIRT3 coordinately increase cellular energy stores and ultimately maintain cellular energy homeostasis. Defects in the pathways controlled by SIRT1…
Citation impact
- FWCI
- 17.51
- Percentile
- 100%
- References
- 380
Authors
10- RNRubén Nogueiras
Harvard University, Yale University, Dana-Farber Cancer Institute, Instituto de Investigación Sanitaria de Santiago, University of Cincinnati
- KMKirk M. Habegger
Harvard University, Yale University, Dana-Farber Cancer Institute, Instituto de Investigación Sanitaria de Santiago, University of Cincinnati
- NCNilika Chaudhary
Harvard University, Yale University, Dana-Farber Cancer Institute, Instituto de Investigación Sanitaria de Santiago, University of Cincinnati
- BFBrian Finan
Harvard University, Yale University, Dana-Farber Cancer Institute, Instituto de Investigación Sanitaria de Santiago, University of Cincinnati
- ASAlexander S. Banks
Harvard University, Yale University, Dana-Farber Cancer Institute, Instituto de Investigación Sanitaria de Santiago, University of Cincinnati
Topics & keywords
- Sirtuin
- SIRT3
- NAD+ kinase
- Sirtuin 1
- Mitochondrion
- Catabolism
- Cell biology
- Biology
- Affordable and clean energy