Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging
National Institutes of Health · National Institute of Dental and Craniofacial Research · +3 more institutions
Abstract
The contribution of stem and progenitor cell dysfunction and depletion in normal aging remains incompletely understood. We explored this concept in the Klotho mouse model of accelerated aging. Analysis of various tissues and organs from young Klotho mice revealed a decrease in stem cell number and an increase in progenitor cell senescence. Because klotho is a secreted protein, we postulated that klotho might interact with other soluble mediators of stem cells. We found that klotho bound to various Wnt family members. In a cell culture model, the Wnt-klotho interaction resulted in the suppression of Wnt biological activity. Tissues and organs from klotho-deficient animals showed evidence of increased Wnt…
Citation impact
- FWCI
- 21.82
- Percentile
- 100%
- References
- 22
Authors
13- HLHongjun LiuCorresponding
National Institutes of Health, National Institute of Dental and Craniofacial Research, Maryland Oncology Hematology, National Heart Lung and Blood Institute
- MMMarı́a M. Fergusson
National Institutes of Health, National Institute of Dental and Craniofacial Research, Maryland Oncology Hematology, National Heart Lung and Blood Institute
- RMRogério M. Castilho
National Institutes of Health, National Institute of Dental and Craniofacial Research, Maryland Oncology Hematology, National Heart Lung and Blood Institute
- JLJie Liu
National Institutes of Health, National Institute of Dental and Craniofacial Research, Maryland Oncology Hematology, National Heart Lung and Blood Institute
- LCLiu Cao
National Institutes of Health, National Institute of Dental and Craniofacial Research, Maryland Oncology Hematology, National Heart Lung and Blood Institute
Topics & keywords
- Wnt signaling pathway
- Klotho
- Progenitor cell
- Senescence
- Cell biology
- Biology
- Ectopic expression
- Stem cell