An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
National Institutes of Health · University of Cambridge · +4 more institutions
Abstract
Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame ("X-ORF"), accessed via ribosomal frameshifting. The frameshift product, termed PA-X, comprises the endonuclease domain of the viral PA protein with a C-terminal domain encoded by the X-ORF and functions to repress cellular gene expression. PA-X also modulates IAV virulence in a mouse infection model, acting to decrease pathogenicity. Loss of PA-X expression leads to changes in the kinetics of the global host response, which notably includes increases in inflammatory, apoptotic, and T lymphocyte-signaling pathways. Thus, we have identified a…
Citation impact
- FWCI
- 48.40
- Percentile
- 100%
- References
- 34
Authors
17- BWBrett W. Jagger
National Institutes of Health, University of Cambridge, National Institute of Allergy and Infectious Diseases
- HWHelen Wise
University of Cambridge
- JCJohn C. Kash
National Institutes of Health, National Institute of Allergy and Infectious Diseases
- KWKathie‐Anne Walters
Institute for Systems Biology
- NMNorma M. Wills
University of Utah
Topics & keywords
- Host response
- Host (biology)
- Virus
- Coding (social sciences)
- Influenza A virus
- Host factors
- Virology
- Computational biology
- Good health and well-being