Coordinated Changes of Mitochondrial Biogenesis and Antioxidant Enzymes During Osteogenic Differentiation of Human Mesenchymal Stem Cells
National Yang Ming Chiao Tung University · Institute of Molecular Biology, Academia Sinica · +3 more institutions
Abstract
The multidifferentiation ability of mesenchymal stem cells holds great promise for cell therapy. Numerous studies have focused on the establishment of differentiation protocols, whereas little attention has been paid to the metabolic changes during the differentiation process. Mitochondria, the powerhouse of mammalian cells, vary in their number and function in different cell types with different energy demands, but how these variations are associated with cell differentiation remains elusive. In this study, we investigated the changes of mitochondrial biogenesis and bioenergetic function using human mesenchymal stem cells (hMSCs) because of their well-defined differentiation potentials. Upon osteogenic…
Citation impact
- FWCI
- 7.44
- Percentile
- 100%
- References
- 30
Authors
5- CCChien-Tsun Chen
National Yang Ming Chiao Tung University, Institute of Molecular Biology, Academia Sinica, National Yang Ming Chiao Tung University
- YVYu‐Ru V. Shih
National Yang Ming Chiao Tung University, National Yang Ming Chiao Tung University
- TKTom K. Kuo
National Yang Ming Chiao Tung University, National Yang Ming Chiao Tung University
- OKOscar K. LeeCorresponding
National Yang Ming Chiao Tung University, Taipei Veterans General Hospital, National Yang Ming University Hospital
- YWYau‐Huei WeiCorresponding
National Yang Ming Chiao Tung University, Institute of Molecular Biology, Academia Sinica, National Yang Ming Chiao Tung University
Topics & keywords
- Cell biology
- Mesenchymal stem cell
- Biology
- Mitochondrial biogenesis
- Glycolysis
- Downregulation and upregulation
- Mitochondrion
- Cellular differentiation
- Affordable and clean energy