Nanoparticle Adhesion to the Cell Membrane and Its Effect on Nanoparticle Uptake Efficiency
University College Dublin · Trinity College Dublin
Abstract
The interactions between nanosized particles and living systems are commonly mediated by what adsorbs to the nanoparticle in the biological environment, its biomolecular corona, rather than the pristine surface. Here, we characterize the adhesion toward the cell membrane of nanoparticles of different material and size and study how this is modulated by the presence or absence of a corona on the nanoparticle surface. The results are corroborated with adsorption to simple model supported lipid bilayers using a quartz crystal microbalance. We conclude that the adsorption of proteins on the nanoparticle surface strongly reduces nanoparticle adhesion in comparison to what is observed for the bare material.…
Citation impact
- FWCI
- 34.22
- Percentile
- 100%
- References
- 44
Authors
6Topics & keywords
- Nanoparticle
- Chemistry
- Adhesion
- Biophysics
- Quartz crystal microbalance
- Membrane
- Surface charge
- Nanotechnology