KaKs_Calculator: Calculating Ka and Ks Through Model Selection and Model Averaging
Chinese Academy of Sciences · Beijing Institute of Genomics · +4 more institutions
Abstract
Abstract KaKs_Calculator is a software package that calculates nonsynonymous (Ka) and synonymous (Ks) substitution rates through model selection and model averaging. Since existing methods for this estimation adopt their specific mutation (substitution) models that consider different evolutionary features, leading to diverse estimates, KaKs_Calculator implements a set of candidate models in a maximum likelihood framework and adopts the Akaike information criterion to measure fitness between models and data, aiming to include as many features as needed for accurately capturing evolutionary information in protein-coding sequences. In addition, several existing methods for calculating Ka and Ks are also…
Citation impact
- FWCI
- 2.32
- Percentile
- 100%
- References
- 44
Authors
6- ZZZhang Zhang
Chinese Academy of Sciences, Beijing Institute of Genomics, Institute of Computing Technology, University of Chinese Academy of Sciences
- JLJun Li
Chinese Academy of Sciences, Beijing Institute of Genomics
- XZXiaoqian Zhao
Chinese Academy of Sciences, Beijing Institute of Genomics, University of Chinese Academy of Sciences
- JWJun Wang
Chinese Academy of Sciences, Beijing Institute of Genomics, Institute of Computing Technology, Zhejiang University
- GKGane Ka‐Shu Wong
Chinese Academy of Sciences, University of Washington, Beijing Institute of Genomics, Zhejiang University
Topics & keywords
- Calculator
- Model selection
- Selection (genetic algorithm)
- Computer science
- Artificial intelligence
- Operating system