Episodic memory loss is related to hippocampal-mediated -amyloid deposition in elderly subjects
University of California, Berkeley · Lawrence Berkeley National Laboratory · +5 more institutions
Abstract
Although beta-amyloid (Abeta) plaques are a primary diagnostic criterion for Alzheimer's disease, this pathology is commonly observed in the brains of non-demented older individuals. To explore the importance of this pathology in the absence of dementia, we compared levels of amyloid deposition (via 'Pittsburgh Compound-B' (PIB) positron emission tomography (PET) imaging) to hippocampus volume (HV) and episodic memory (EM) in three groups: (i) normal controls (NC) from the Berkeley Aging Cohort (BAC NC, n = 20); (ii) normal controls (NC) from the Alzheimer's disease neuroimaging initiative (ADNI NC, n = 17); and (iii) PIB+ mild cognitive impairment subjects from the ADNI (ADNI PIB+ MCI, n = 39). Age, gender…
Citation impact
- FWCI
- 23.94
- Percentile
- 100%
- References
- 72
Authors
11- ECElizabeth C. MorminoCorresponding
University of California, Berkeley
- JTJenny T. Kluth
Lawrence Berkeley National Laboratory
- CMCindee Madison
University of California, Berkeley
- GDGil D. Rabinovici
University of California, Berkeley, Lawrence Berkeley National Laboratory, University of California, San Francisco, University Memory and Aging Center
- SLSuzanne L. Baker
Lawrence Berkeley National Laboratory
Topics & keywords
- Pittsburgh compound B
- Alzheimer's Disease Neuroimaging Initiative
- Dementia
- Neuroimaging
- Psychology
- Hippocampus
- Positron emission tomography
- Episodic memory
- Quality Education