A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
University of California, Los Angeles · University of Zurich · +1 more institution
Abstract
Recent human imaging and animal studies highlight the importance of frontoamygdala circuitry in the regulation of emotional behavior and its disruption in anxiety-related disorders. Although tracing studies have suggested changes in amygdala–cortical connectivity through the adolescent period in rodents, less is known about the reciprocal connections within this circuitry across human development, when these circuits are being fine-tuned and substantial changes in emotional control are observed. The present study examined developmental changes in amygdala–prefrontal circuitry across the ages of 4–22 years using task-based functional magnetic resonance imaging. Results suggest positive amygdala–prefrontal…
Citation impact
- FWCI
- 23.66
- Percentile
- 100%
- References
- 78
Authors
9Topics & keywords
- Amygdala
- Psychology
- Prefrontal cortex
- Functional magnetic resonance imaging
- Neuroscience
- Functional connectivity
- Ventromedial prefrontal cortex
- Cognition