GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Harvard University · Massachusetts General Hospital · +2 more institutions
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Abstract
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2,291
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Authors
12- SQShengdar Q. TsaiCorresponding
Harvard University, Massachusetts General Hospital, Center for Cancer Research
- ZZZongli Zheng
Harvard University, Karolinska Institutet, Massachusetts General Hospital, Center for Cancer Research
- NTNathalie T. Nguyen
Massachusetts General Hospital, Center for Cancer Research
- MLMatthew Liebers
Massachusetts General Hospital, Center for Cancer Research
- VVVed V. Topkar
Massachusetts General Hospital, Center for Cancer Research
Topics & keywords
Topics
Keywords
- CRISPR
- Computational biology
- Genome
- Biology
- Chromatin
- Genome editing
- DNA sequencing
- Guide RNA
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