Bone marrow–derived progenitor cells in pulmonary fibrosis
University of Michigan–Ann Arbor · Michigan Medicine
Abstract
The origin of fibroblasts in pulmonary fibrosis is assumed to be intrapulmonary, but their extrapulmonary origin and especially derivation from bone marrow (BM) progenitor cells has not been ruled out. To examine this possibility directly, adult mice were durably engrafted with BM isolated from transgenic mice expressing enhanced GFP. Induction of pulmonary fibrosis in such chimera mice by endotracheal bleomycin (BLM) injection caused large numbers of GFP(+) cells to appear in active fibrotic lesions, while only a few GFP(+) cells could be identified in control lungs. Flow-cytometric analysis of lung cells confirmed the BLM-induced increase in GFP(+) cells in chimera mice and revealed a significant increase in…
Citation impact
- FWCI
- 49.63
- Percentile
- 100%
- References
- 46
Authors
5- NHNaozumi Hashimoto
University of Michigan–Ann Arbor
- HJHongjian Jin
University of Michigan–Ann Arbor, Michigan Medicine
- TLTianju Liu
Michigan Medicine, University of Michigan–Ann Arbor
- SWStephen W. Chensue
University of Michigan–Ann Arbor, Michigan Medicine
- SHSem H. PhanCorresponding
Michigan Medicine, University of Michigan–Ann Arbor
Topics & keywords
- Bone marrow
- Pulmonary fibrosis
- Progenitor cell
- Medicine
- Progenitor
- Pathology
- Fibrosis
- Biology