Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity
Chinese University of Hong Kong · Cornell University · +3 more institutions
Abstract
Long-term memory is thought to be mediated by protein synthesis-dependent, late-phase long-term potentiation (L-LTP). Two secretory proteins, tissue plasminogen activator (tPA) and brain-derived neurotrophic factor (BDNF), have been implicated in this process, but their relationship is unclear. Here we report that tPA, by activating the extracellular protease plasmin, converts the precursor proBDNF to the mature BDNF (mBDNF), and that such conversion is critical for L-LTP expression in mouse hippocampus. Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression.
Citation impact
- FWCI
- 15.92
- Percentile
- 100%
- References
- 31
Authors
10- PTPetti T. PangCorresponding
Chinese University of Hong Kong, Cornell University, National Institute of Child Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Health and Human Development (2HD) Research Network
- HTHenry Teng
Chinese University of Hong Kong, Cornell University, National Institute of Child Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Health and Human Development (2HD) Research Network
- EZEugene Zaitsev
Chinese University of Hong Kong, Cornell University, National Institute of Child Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Health and Human Development (2HD) Research Network
- NTNewton T. Woo
Chinese University of Hong Kong, Cornell University, National Institute of Child Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Health and Human Development (2HD) Research Network
- KSKazuko Sakata
Chinese University of Hong Kong, Cornell University, National Institute of Child Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Health and Human Development (2HD) Research Network
Topics & keywords
- Long-term potentiation
- Hippocampal formation
- Plasmin
- Cell biology
- Synaptic plasticity
- Neuroscience
- Tissue plasminogen activator
- Plasminogen activator